Abstract
A PILOT STUDY TO CLINICALLY EVALUATE THE EFFICACY AND SAFETY OF A HERBOMINERAL PREPARATION ‘VATNIVRITI’ IN PATIENTS WITH PRIMARY ASYMPTOMATIC HYPERURICEMIA

*Dr. Ruchika Nandha, Dr. Suruchi Aditya, Dr. Kavita Sekhri, Dr. Shashi Prakash Tiwari and Dr. Kamlesh Garg

ABSTRACT

In lieu of the fact that Ayurveda is an effective and safe option in many diseases, its role in primary asymptomatic hyperuricemia has also been illustrated in Indian literature. Aims and objectives: The present study is planned to investigate the clinical efficacy and safety of a herbomineral medicine ‘Vatnivriti’ in treating primary asymptomatic hyperuricemia. Methods: An open label prospective study was conducted at Shri Ashutosh Maharaj (SAM) ayurvedic treatment centre, Nurmahal, Punjab. 60 patients in the age group 24–65 years having primary hyperuricemia and generalized body pains with serum uric acid levels more than 7mg/dl without any co-morbid illness but with a strong family history of gout were enrolled, out of which 56 patients completed the study. Patients were treated with Capsule Vatnivriti 500 mg twice a day with milk. Results: Primary efficacy end point (serum uric acid level less than 6mg /dl) was achieved in 53.57% patients at week 6 and 82.10% of patients at week 12. Percentage change in mean uric acid levels was 23.68 ±13.10 at week 6 and 32.34±13.82 at week 12 with a statistically significant difference from baseline value(P<0.0001). At week 12, percentage decrease in mean uric acid levels was significantly higher by 10.868±13.485 from week 6 (p<0.0001). Complete relief of pain was observed in 48 patients while 8 patients showed reduction in pain severity as determined by Numeric Rating Scale. Only 2 patients complained of nausea. Conclusion: Vatnivriti offers an efficacious and safe combination of natural products for the treatment of hyperuricemia.

Keywords: Hyperuricemia, Gout, Uric acid, Vatnivriti.


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