European Journal of Biomedical and Pharmaceutical Sciences

A CASE STUDY ON PYODERMA GANGRENOSUM – AN INFLAMMATORY NEUTROPHILIC DERMATOSES

S.P. Akshara*, M. Arumugavignesh, M. Abdulla, P. Jeevitha Lakshmi, P. Jessica

ABSTRACT

Pyoderma gangrenosum is a reactive non-infectious inflammatory dermatoses falling under the spectrum of the neutrophilic dermatoses. Pyoderma gangrenosum is not caused by infection or gangrene. There is a female predominance in this disease. Presenting a clinical case of a young female patient with Pyoderma gangrenosum and discussing about her disease‟s pathophysiology along with treatment provided for her is the specific objective of this case study. A 27 years old female patient with complaints of fluid filled pustules, dark colored and itchy patches over the legs for the past four months was admitted to the general medicine department of the hospital. On investigation, blood report showed that the patient was anaemic. The local examination of patient revealed the presence of multiple hyper pigmentation and dark coloured plaques with oozing over both legs. The patient had been given cefotaxime 1g intravenously every twelve hourly. Ranitidine 50mg was administered before food every twelve hourly via intravenous route. The given antibiotics for this patient were indicated towards the treatment of eczema, which is feared to be a complication of pyoderna. The lesions were only partially healed by treating with antibiotics. For complete remission, immunosuppressants and corticosteroids therapy is absolutely necessary for this patient. Anaemia is often under diagnosed in these busy hospital settings. It must be properly monitored in order to avoid complications associated with anaemia in women of child-bearing age.

Keywords: Pyoderma gangrenosum, corticosteroids, immunosuppressants, anaemia.