Abstract
FORMULATION AND IN VITRO EVALUATION OF ATORVASTATIN ORODISPERSIBLE TABLETS USING SODIUM STARCH GLYCOLATE AND CROSS POVIDONE AS SUPERDISINTEGRANT

Mohd Shoukhatullah Ansari*, Afshan Sultana, Niranjan Panda, Sumayya Ather Siddiqui, Aroosa Nahid and Sana

ABSTRACT

The current study’s goal was to create an orodispersible Atorvastatin tablet using various concentration of Sodium starch glycolate and Cross Povidone as superdisintegrant in order to achive rapid disintegration in gastric pH and quick action to lower cholesterol and triglyceride (fats) levels in the blood. A class of drugs known as HMG-CoA reductase inhibitors (statins) includes Atorvastatin. Wet granulation technology was used to formulate ten distinct Atorvastatin orodispersible tablet formulations. Studies on the compatibility of drug and excipients using FTIR technology revealed that there is no interaction between the drugs and the various excipients used in the formulation. The results of various precompression and post compression characterizations of tablets were satisfactory when compared to the pharmacopoeia. For several formulations, in vitro release tests were performed using a USP II paddle type dissolution apparatus. The formulation containing 4% crosspovidone (AODT4) provided the best release profile, or about 99% within 20 minutes. In vitro release kinetic studies like zero order, first order kinetic model were carried out for best formulation. The best formulation followed zero order kinetic model. To verify the stability of dosage forms, accelerated stability experiments were conducted for optimised formulation.

Keywords: Atorvastatin, Orodispersible tablet, Sodium starch glycolate, Cross Povidone, anticholesteremic.


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