European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SCHIFF BASE 4-THAIZOLIDINONES OF AMINOSALICYLIC ACID DERIVATIVES

Raghvendra Gour*, Balkrishana Dubey and Deepak Basedia

ABSTRACT

Keeping in view the pharmacological potential of thiazolidinones and 4- aminosalicylicacid derivatives, the title compounds containing these nuclei were synthesied.Reaction of 4-aminosalicylic acid(I) with substituted 2-chloro(3a-d),2- hydroxy(4a-d) and 2-thio(5a)-3-formylquinolines (M1-9) in presence of catalytic amount of glacial acetic acid in refluxing ethanol afford Schiff ‘ s bases. Further, cyclization of compounds (M1-9) with thioglycolic acid in 1, 4-Dioxan in presence of anhydrous ZnCl2 furnished desired novel compounds (MS1-9). The newly synthesized compounds were characterized by spectroscopic and physical methods. All the synthesized compounds were screened for antibacterial and antifungal activity by standard methods. Results of the anti-microbial study reveals that, some compounds exhibited moderate to good anti-bacterial and anti-fungal activities.

Keywords: p-aminosalicylic acid, thiazolidinone, Quinoline, Cyclocondensation, vilsmeier reagent, Schiff’s bases, thioglycolic acid.