Abstract
FORMULATION & EVALUATION OF SUSTAINED RELEASE MUCOADHESIVE MICROSPHERES

Shivangi Singh*, Dr. Neelima Goswami and Dr. R. B. Goswami

ABSTRACT

Mucoadhesive microspheres can be tailored to adhere to any mucosal tissue including those found in eye, nasal cavity, urinary and gastrointestinal tract, thus offering the possibilities of localized as well as systemic controlled release of drugs.microspheres used for Vaccine delivery for treatment of diseases like hepatitis, influenza, pertusis, ricin toxoid, diphtheria, birth control and also used for Passive targeting of leaky tumour vessels, active targeting of tumour cells, antigens, by intra-arterial/intravenous application. In the present work, an organoleptic characteristic of drug is determined and it seems to be yellow crystalline powder, tasteless and odourless. Its melting point is 3320C and solubility was determined in different solvents and found freely soluble in DMSO and other solvents. The standard curve of Meletine in hydroalcholic solution was drawn at 370nm by taking different aliquots, a line is obtained with the regression value r2=0.981. Then the interaction study between the drug and polymer done and considered as compatible i.e. there is no interaction between drug and polymer mixture. The In-vitro release study of different batches were done at different time intervals in which % cumulative release is determined by considering drug release at 210 min as 100% drug release by following first order kinetics. The graph is plotted between % cumulative release v/s time and a semi log graph is plotted between log % cumulative release v/s time. Finally Mucoadhesive strength of different batches were determined and found that the batch F6 showed maximum mucoadhesion. Hence Meletine can be formulated as Mucoadhesive microsphere and in this Meletine can be utilized for its protective efficacy as antidote to mustard agents particularly for sustained release, protection of mucosal membrane and in case of accidental ingestion.

Keywords: Microspheres, Mcoadhesive, Sustain Released, Meletin.


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