Abstract
RESEARCH ARTICLE ON SUBACUTE INTRAMUSCULAR TOXICITY STUDY OF AQUEOUS CHOLECALCIFEROL IN WISTAR RATS

Ritu R. Raval*, Nilesh J. Patel, Chintan Patel, Jayesh Patel and Rikesh Patel

ABSTRACT

In the market there are multiple choices available for vitamin D supplements. We prepared aqueous cholecalciferol novel drug preparation use in the behalf of oil soluble vitamin-D accretion for more rapidly efficiency. Vitamin-D is a dietary supplement which is using for multipurpose. The main source of cholecalciferol is sunlight and dairy foods. We hypothesized that aqueous cholecalciferol would be beneficial than oil soluble preparations and found out no possible toxicity in wistar rats. Forty-eighth female and male wistar rats were divided into four group (n=6): group1 (placebo-IM), group 2 (62000 IU/kg cholecalciferol-IM), group 3 (93000 IU/kg cholecalciferol-IM) and group 4 (124000 IU/kg cholecalciferol-IM). The result, including body weight, feed intake, hematological, biochemical parameters in all different groups did not reveal any abnormality related to aqueous cholecalciferol.

Keywords: Aqueous cholecalciferol, Calcium, Rickets, Parathyroid hormone, Osteoporosis.


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