European Journal of Biomedical and Pharmaceutical Sciences

ANTIDIABETIC EFFECTS OF EXTRACT ETHANOL MOMORDICA CHARANTIA (BITTER MELON) ON GLUCOSE BLOOD IN DIABETEC RATS

Erdawati* and Ristin Syahruddin

ABSTRACT

This study aims to determine the content of active compounds from the ethanolic extract of bitter melon and the effect of bitter melon extract on blood glucose levels of diabetic rats induced by alloxan. This study was conducted in vivo to determine the decrease in blood glucose levels during therapy with ethanol extract of bitter melon. Mice were conditioned hyperglycemic by using alloxan. This study used 18 male white rats which were divided into 6 groups, namely normal control, positive control, and 4 dose variation controls. The dose used is 1 mL; 0.80 mL; 0.60 mL; 0.45 mL/200 g BW. Therapy was carried out for 14 days by measuring blood glucose levels on days 2, 4, 5, 6, 8, 10, 12, and 14 after therapy. Phytochemical test results of ethanol extract of bitter melon contains alkaloids, tannins, saponins and terpenoids. Therapy with ethanol extract of bitter melon showed the effect of treatment time on reducing blood glucose levels of alloxan-induced rats. The time needed is 14.6 days to reach blood glucose levels when they become normal.

Keywords: Bitter melon, aloxan, mice, glucose blood.