European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL SERIES OF HYDROXAMIC ACIDS

Taibi Houria, Zerkout Said* and Bekdouche Hafsa

ABSTRACT

This study aims to prepare a novel series of non- cyclic hydroxamic acids which they are Currently occupies a wide fields because of their remarkable biological activities, through the Synthesis of nitrones by the condensation of aldehydes and derivatives of aromatic or aliphatic hydroxylamine as a first step, then these nitrones were oxidized by lead Tetra –acetate (LTA) to give N-acetoxy amide derivatives as a second step, which were hydrated in the acid middle to obtain the approval hydroxamic acids as a last step. Structures of the synthesized compounds were established by elemental analyses, FT-IR, 1HNMR. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. The bioassays indicated that most of the synthesized compounds exhibited moderate to significant antibacterial and antifungal activities.

Keywords: Nitrones , Acetoxy amide derivatives, hydroxamic acids , biological tests, elemental analyses.