A REVIEW ON BENZIMIDAZOLE-BASED MEDICINAL CHEMISTRY
M. Gnana Ruba Priya*, Vasanth Kumar, Pooja C., Y.S. Vidyashree, Nehakumari A. Sah and Mohamed Yousuf Aslam S.
ABSTRACT
Benzimidazole is an aromatic, heterocyclic and bicyclic organic compound. It is the combination of imidazole and
benzene ring which exhibits potential pharmacological actions such as anti-microbial, anti-cancer, anti-viral,
analgesic, anti-protozoal, anti-tubercular, anthelmintic and more. Various methods for benzimidazole preparation
and their various reaction gave great scope in medicinal chemistry. There are several drugs which are available for
treating the diseases but have several side effects so there is a need for synthesizing better efficacy and novel
mechanism of action. Benzimidazole ring is essential pharmacophore for discovery of new drugs. There are many
ongoing researches for this compound because of its versatility, it would help in obtaining many better medicinal
agents.
Keywords: Benzimidazole, anti-microbial activity, synthesis of benzimidazole, anti-cancer activity, anti-viral activity and anti-protozoal activity.
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