European Journal of Biomedical and Pharmaceutical Sciences

PHARMACOTHERAPY OF ULCER

*Sonawane A.R., Andhale A.K., Waghmare S.A., Kamble H.V.

ABSTRACT

Peptic ulcer is a chronic disease affecting up to 10% of the world’s population. The formation of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two major factors disrupting the mucosal resistance to injury. Conventional treatments of peptic ulcers, such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists have demonstrated adverse effects, relapses, and various drug interactions. On the other hand, medicinal plants and their chemical compounds are useful in the prevention and treatment of numerous diseases. Hence, this review presents common medicinal plants that may be used for the treatment or prevention of peptic ulcers. In the last one hundred years much has been written on peptic ulcer disease and the treatment options for one of its most common complications perforation. The reason for reviewing the literature was evaluating most common ideas on how to treat perforated peptic ulcers (PPU) in general, opinions on conservative treatment and surgical treatment and summarizing ideas about necessary pre-, and perandpostoperative proceedings.

Keywords: chronic disease, Helicobacter Pylori infection, conventional treatment, Medicinal treatment.