Abstract
THE DISTRIBUTION OF ALTERED FORMS OF CYP2C19*2 ALLELE IN A TRINIDADIAN POPULATION. IS CLOPIDOGREL THE RIGHT CHOICE?

Mungrue K*, Wyke M, Ramkissoon V, Griffith I, Ramnath M, Verma A, Carmichael C, Soo Ping Chow M, O’Brien K and Mark A.

ABSTRACT

Wyke M, Ramkissoon V, Griffith I, Ramnath M, Verma A, Carmichael C, Soo Ping Chow M, Mungrue K, O’Brien K and Mark A. University of the West Indies, Faculty of Medical Sciences, Department of Paraclinical Sciences Public Health & Primary Care Unit & Department of Preclinical Sciences, Biochemistry Unit Eric Williams Medical Sciences Complex, St Augustine Trinidad and Tobago. Objective: To determine the distribution of the CYP2C19*2 allele among Trinidadians. Design and Method: This is a cross sectional study among 100 patients attending primary health centers within the North Central Region of Trinidad. We used a stratified sampling technique in which there were three mutually exclusive subgroups South East Asians, Africans and mixed ethnicity. Subsequently systematic sampling was applied to each stratum to improve the representativeness of the sample. Hence the 100 subjects recruited for the study were 40 South East Asians, 40 Africans and 20 of mixed decent. Apart from baseline data which included age, gender and ethnicity DNA was assessed for the CYP2C19*2 allelic variant using a real time PCR method. Results: There was a high proportion (37%) of Allelic frequencies for CYP2C19*2 which was found to more common among South East Asian (47.5%, 95% CI 32.0-63.0) who also have high prevalence of CHD than Africans (45%, 95% CI 23.2-66.8) or people of mixed origin (95% CI 9.6- 35.4),. Conclusion: In conclusion we provide evidence that the prevalence of CYP2C19*2 mutations are high in our setting.

Keywords: To determine the distribution of the CYP2C19*2 allele among Trinidadians.


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