European Journal of Biomedical and Pharmaceutical Sciences

A COMPREHENSIVE DOCKING STUDY REVIEW OF PHARMACOGNOSTIC, PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF ACACIA AURICULOFORMIS A.CUNN.EX BENTH. WITH IMMUNOMODULATORY ACTIVITY

Abhijit Sasmal*, Deeparani Urolagin, Sourav Pakrashy, Tania Sadhu and Chanchal Koley

ABSTRACT

Immunomodulatory treatment is often required beneath the conditions of impeded safe responsiveness and when the resistant components have got to be actuated. Even while normal immunomodulatory chemotherapy is available, it is so expensive that it is frequently out of reach of average socioeconomic people. As a result, the balancing of safe framework by conventionally used medicinal plant products has become a topic for recent logical studies all over the world. The perennial shrub Acacia auriculiformis A.Cunn. ex Benth. is widely dispersed throughout the world and has a variety of therapeutic potentials. It has been used traditionally to treat a variety of medical issues, including allergies, rheumatism, sore eyes, pains, and rashes. Due to its low toxicity (LD50 = 3741.7 mg/kg) and high efficacy, Acacia auriculiformis has also been shown to have numerous pharmacological effects, including central nervous system depressant activity, antioxidant, antimicrobial, antimalarial, anti-filarial, cestocidal, antimutagenic, chemopreventive, spermicidal, wound healing, hepatoprotective, and antidiabetic. The presence of the main components- flavonoids (Auriculoside) and triterpenoid saponin glycosides (acaciasides- acaciaside A & B) in various portions of this plant is also demonstrated by numerous phytochemical analysis. Researchers have been doing several investigations on this medicinally significant plant for many years in an effort to elicit the diverse biological actions. Significant effectiveness was shown in the numerous plant extracts tested for diverse pharmacological actions. The plant's bioactive phytoconstituents that have been isolated from various plant sections are emphasised for different pharmacological activity. It is also said that the plant underwent pharmacognostical standardisation using multiple standards characteristics. This plant's low toxicity and the presence of important bioactive phytoconstituents including flavonoids and triterpenoid, saponin glycosides are what make it useful as a drug treatment for numerous illnesses. In-depth, details regarding the pharmacognostic, phytochemical, and pharmacological studies of Acacia auriculiformis to date as well as the plant's immunomodulatory properties are included in this article.

Keywords: Immunomodulatory, Acacia auriculoformis, antimicrobial, antioxidant, cestocidal, Antifungal, Antifilarial.