European Journal of Biomedical and Pharmaceutical Sciences

DESIGN ANDIN-VITRO EVALUATION OF FAST DISSOLVING TABLETS OF AMLODIPINE

K. S. Srilatha*, Monika Shringi, Amartya Guria, Baibhav Kumar, Lubina Mol Salim and Rakesh Yadav

ABSTRACT

The objective of the study was to design and evaluate fast dissolving tablets of Amlodipine, it is a calcium channel blocker works by affecting the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure, and increase the supply of blood and oxygen to the heart while reducing its workload. It has a bioavailability 64% -90%. Amlodipine showed maximum absorbance at 242nm so absorbance was measured at the same wavelength and found to obey Beer lamberts law in the concentration range of 10-40 mcg/ml. In the pre formulation study of IR spectra of pure drug with the different Super disintegrants was studied, no interactions were observed. 8 formulation of Amlodipine fast dissolving tablets were prepared by direct compression and they were examined for physical properties and appearance like hardness, thickness, weight variation, thickness, hardness, friability uniformity of drug content and in-vitro drug release studies. All the parameters were within the limits.[1]

Keywords: Amlodipine fast dissolving tablets, Super disintegrants and sodium starch glycolate.