Abstract
FORMULATION AND EVALUATION OF CHITOSAN NANOPARTICLES OF ESOMEPRAZOLE FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE

Shashwat Singh*, Vinod Kumar Dhote, Kanika Dhote and Surendra Jain

ABSTRACT

Gastroesophageal reflux disease (GERD) is a condition in which the digestive acid in the stomach comes in contact with the esophagus. The irritation caused by this disorder is known as heartburn. Long-term contact between gastric acids and the esophagus can cause permanent damage to the esophagus. Esomeprazole reduces the production of digestive acids, thus reducing their effect on the esophagus. Esomeprazole is a proton pump inhibitor which reduces acid secretion through inhibition of the H+/ K+ ATPase in gastric parietal cells. Esomeprazole having a shorter biological half life (1-1.5 hours) hence we are selected as a chitosan nanoparticles, So it should be improve the bioavailability, reduce the number of doses, maintain constant therapeutic levels of the drug over 24 hours and to increase patient compliance for the treatment of gastroesophageal reflux disease, zollinger ellison syndrome and peptic ulcer disease. The purpose of the present study was to prepare and evaluate the chitosan nanoparticles of esomeprazole for the treatment of GERD by ionic gelation method. Nanoparticles were subjected to various characterization techniques such as FTIR, particle size, scanning electron microscopy (SEM), drug entrapment efficiency, in-vitro release studies and zeta potential are also determined for the developed formulations. The entrapment efficiencies were found to be minimum and maximum of 40.65±1.22% and 64.85±1.50%, the optimum entrapment efficiency was found to be 64.85±1.50%, particle size varied from 215.57nm to 257.74nm, the zeta potential of the best chitosan preparation (F2) was found to be -30.5mV, which confirms the stability of prepared nanosuspension. In-vitro release of drug follows first order and showed sustained release behavior for a period of 24 hr. The study demonstrated the successful preparation of sustained release polymeric nanoparticles of esomeprazole. KEYWORDS: Gastroesophageal reflux disease, Esomeprazole, Chitosan nanoparticles, Ionic gelation method.

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