European Journal of Biomedical and Pharmaceutical Sciences

DESIGN AND CHARACTERIZATION OF NANOEMULGEL CONTAINING GRISEOFULVIN

Shripathy D.*, Sneha V. and Shabaraya A.R.

ABSTRACT

Nanoemulgel have emerged as one of the most interesting topical drug delivery system as it has dual release control system i.e. Nanoemulsion and gel. When gels and emulsions are used in combined form the dosage form are known as emulgel. Griseofulvin is an antifungal medication topically administerd to treat skin infections such as jock itch, athlete’s foot and ring worm. The aim of the present research work was to investigate the potential of Nanoemulgel in enhacing the topical delivery of hydrophobic drug. Grseofulvin Nanoemulsions were prepared using span80, tween 80, propylene glycol and clove oil by high speed homogenization.Pseudo ternary phase diagram was generated by using water titration method. The prepared Nanoemulsions were evaluated for pH, drug content, centrifugation, globule size and zeta potential. Nanoemulgel was prepared by using carbopol 934 as gelling agent. Best formulation GF5 showed a maximum drug release of 83.42±0.03 in 8 hours, particle size of 51.9 nm and zeta potential of -24.6 mV. GF5 showed highest drug content 90%. The release kinetics of Nanoemulgel was found to obey zero order kinetics. The Nanoemulgel was found to be stable with respect to physical appearance, pH, rheological properties, spreadability and drug content at all temperature and conditions for two months. Thus, it can be concluded that Griseofulvin Nanoemulgel formulation is a promising system for the topical drug delivery and also an alternative method to deliver the hydrophobic drug in water soluble gel bases.

Keywords: Nanoemulsion, Nanoemulgel, Topical drug delivery.