European Journal of Biomedical and Pharmaceutical Sciences

DRUG UTILIZATION EVALUATION OF ANTIHYPERTENSIVE DRUGS IN TERTIARY CARE HOSPITAL

Dr. Ganesh Prasad Jaiswal*, Dr. Mihir Kumar Biswas, Dr. Beulah Milton, Dr. L. Padma and
Dr. Narayanaswamay V.B.

ABSTRACT

Introduction: Hypertension, also known as high or elevated blood pressure, is a condition in which the blood vessels have persistently raised pressure. Objective: TO conduct a retrospective and prospective study on drug utilization evaluation of antihypertensive drugs.Methodology: Drug use utilization data of 150 patients, attending inpatients and out patient’s department of Sapthagiri Hospital was collected from patient’s case Notes and prescriptions. This study is retrospective and prospective observational study. The data were analysed to find out the demographic characteristics of the patients, number of drugs prescribed per patients, drugs which are commonly prescribed, mono therapy, combination therapy (two drug therapy, three drug therapy), route of administration, adherence with JNC VIII, drug treatment based on stages of hypertension, co-morbidities of patients. Patients suffering from hypertension with or without co-morbid conditions were included in the study. Result: During the 6-month period of study 150 prescription for Hypertension were analysed. Among 150 prescriptions most of the patients were female (56.66%) while (43.33%) were male and major age group having HTN was found to be 51-60 years (30.66%). Regarding co-morbidity 33.33% patients had HTN with DM. the study revealed that most of the patients were on combination therapy of anti-hypertensive drugs (63.33%) while 36.66% patients received mono therapy. Mostly prescribed rout of administration was oral route (86.66%). Among 150 prescriptions 85.34% of prescription were found to be adhered with JNC VIII guidelines. Conclusion: 14.67% deviation from JNC VIII guidelines and 16.67% prescription had drug interaction was observed in the treatment with respect to selection of antihypertensive drugs.

Keywords: drug utilization, co-morbidities, antihypertensive, JNC VII, DI.