Abstract
FORMULATION AND EVALUATION OF MATRIX TABLETS OF RASAGILINE MESYLATE USED IN THE TREATMENT OF PARKINSON’S DISEASE

Mohammad Ali*, Abdul Razak A., Hemanth Kumar S., Irene Roy., Mohammed Arshad KN.

ABSTRACT

The aim of the present study was to formulate and evaluate Matrix tablet containing Rasagiline Mesylate used in the treatment of Parkinsonism disease. In the present work, an attempt is made to develop controlled-release matrix tablets of Rasagiline Mesylate, with the use of various hydrophilic polymers for their controlling effect. Wet granulation technique is used for tablet formulation along with the addition of suitable additives by using of hydrophilic polymers like Acacia, Ethyl Cellulose. In vitro drug release of F6 was 78.125 % with different concentration of Acacia and Ethyl Cellulose shows maximum drug release and good stability than compared to other formulation. In this study, a controlled release matrix tablet of Rasagiline Mesylate was developed with desirable drug release properties. Higher concentration of polymers containing formulation had good stability, better in vitro release. Therefore, the higher concentration of polymers containing formulation to have the potential to improve the patient compliance, a controlled release formulation of Rasagiline Mesylate, to minimize the frequent dose, to prolong the pharmacological effect.

Keywords: Matrix tablet, Controlled release, Rasagiline Mesylate, Parkinsonism, In vitro release.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MARCH ISSUE PUBLISHED

    MARCH 2024 Issue has been successfully launched on 1 MARCH 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT