FORMULATION AND EVALUATION OF MATRIX TABLETS OF RASAGILINE MESYLATE USED IN THE TREATMENT OF PARKINSON’S DISEASE
Mohammad Ali*, Abdul Razak A., Hemanth Kumar S., Irene Roy., Mohammed Arshad KN.
ABSTRACT
The aim of the present study was to formulate and evaluate Matrix tablet containing Rasagiline Mesylate used in the treatment of Parkinsonism disease. In the present work, an attempt is made to develop controlled-release matrix tablets of Rasagiline Mesylate, with the use of various hydrophilic polymers for their controlling effect. Wet granulation technique is used for tablet formulation along with the addition of suitable additives by using of hydrophilic polymers like Acacia, Ethyl Cellulose. In vitro drug release of F6 was 78.125 % with different concentration of Acacia and Ethyl Cellulose shows maximum drug release and good stability than compared to other formulation. In this study, a controlled release matrix tablet of Rasagiline Mesylate was developed with desirable drug release properties. Higher concentration of polymers containing formulation had good stability, better in vitro release. Therefore, the higher concentration of polymers containing formulation to have the potential to improve the patient compliance, a controlled release formulation of Rasagiline Mesylate, to minimize the frequent dose, to prolong the pharmacological effect.
Keywords: Matrix tablet, Controlled release, Rasagiline Mesylate, Parkinsonism, In vitro release.
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