Abstract
SOLID SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF PROCHLORPERAZINE MALEATE USING ANHYDROUS LACTOSE AS ADSORBENT

Shripathy D.*, Sharvani and A.R. Shabaraya

ABSTRACT

Self-micro emulsifying drug delivery system is one of the promising drug delivery systems among the other lipid-based drug delivery systems. These are mainly used for the delivery of poorly water soluble drugs which are known to show less oral bioavailability. These are commonly dispensed in the form of liquids but due to some of the disadvantages these are solidified and thus either compressed as tablets or filled in the capsules for dispensing. The present study involves the solidification of the liquid self-micro emulsifying drug delivery system of prochlorperazine maleate by adsorption technique using anhydrous lactose as adsorbent. The prepared S-SMEDDS showed the percentage drug content 93.78 ±4.1463 %, and SEM showed that the formulation had microparticles without aggregation. The in-vitro dissolution profile of the drug from the S-SMEDDS (OF1SAL) was 91.11± 0.09 % in 60 minutes which was more than the pure drug and L-SMEDDS. Accelerated stability studies was performed at 400C ± 20 C and 75% ± 5% RH and found to be satisfactory. Thus, it can be concluded that a lipid-based drug delivery system in the solid form can be successfully developed with the potential of enhancing the solubility, dissolution, and oral absorption of the drug.

Keywords: S-SMEDDS, adsorbents, stability, self-emulsification.


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