European Journal of Biomedical and Pharmaceutical Sciences

COVID-19 VACCINES AND ALTERATIONS IN MENSTRUAL CYCLE-A MATTER OF CONCERN?

Arshiya Mubeen Batool*, Neha Fatima, Farzana Shereen, Tanuja Paipuru and C. Uma Sree Devi

ABSTRACT

A prospective observational study was conducted among the South Indian female population in the gynecology department of the tertiary care hospital in Hyderabad, Telangana. for a period of 13 months in 352 patients from September 2021 to October 2022. Our study aimed to analyze the menstrual changes experienced by these women after the administration of the first and second doses of the COVID-19 vaccines available in the Indian market, namely, Covishield, Covaxin, and Sputnik V. The patient’s responses before and after vaccination were recorded. A follow-up was conducted after their first and second doses of vaccination, respectively, and baseline characteristics were observed, recorded, and evaluated to determine the effects of these vaccinations on the menstrual cycle. In the study conducted, 165 females, were in the age group of 15–24 years. 140 females, were 25–34 years old. 35 females,were 35–44 years old. 12 females, were in the age group of 45–54 years. In the given study population, comorbid disease conditions were observed in 11 females with asthma, 12 females with diabetes mellitus, 4 females with hypertension, and 30 females with thyroid disease. 34 females had PCOD, and 5 females had other underlying comorbidities. Among 352 females, 71 (20.2%) of them were vaccinated by Covaxin, 261 (74.1%) were vaccinated by Covishield, and 20 (5.7%) were vaccinated by Sputnik V. Changes in menstrual cycle such as duration,flow, changes in abdominal pain or cramps, changes in vaginal discharge episodes, and body pain or leg pain after the first and second doses of vaccination was recorded. The changes were found to be reversible and not a matter of concern for the majority of the study population, which is 79.8%.e also included in the study.

Keywords: Side effects of COVID-19 vaccines, menastrual cycle abnormalities, SARS-COV2, NSAIDS, female, Menstruation, gynecology.