Abstract
A NOVEL APPROACH OF PHENYTOIN PELLETS FOR MANANGEMENT OF EPILEPSY

Shripathy D.*, Swathi K. and Shabaraya A. R.

ABSTRACT

Oral route is the oldest and convenient route for the administration of therapeutic agents because of low cost of therapy and ease of administration leads to higher level of patient compliance. Phenytoin is an antiepileptic agent which is regarded as first line, first choice of drug to treat epilepsy during pregnancy. The pellets designed and are prepared by extrusion-spheronization method. The aim of the present research work was to investigate the potential of phenytoin pellets in management of epilepsy. The polymers used in the formulation are Eudragit, hypo methoxy cellulose, xanthan gum. The formulations were evaluated for various physicochemical parameters. The Scanning Electron Microscopy photographs confirmed that the prepared formulations were spherical in nature. The compatibility between drug and polymers in the drug loaded pellets was confirmed by Fourier Transform Infra Red spectroscopy studies. The mean particle size of the drug loaded pellets was in the range 1340-1382μm. The percentage drug content was in the range of 92.88 – 98.12%. In-vitro drug release studies are carried out and the evaluation results obtained showed that the formulation F8 showed a maximum drug release of 96.75 % in 12 hours. Stability studies indicated that pellets are stable.Thus it concludes that sustained drug release of pellets helps in better management of epilepsy.

Keywords: Pellets, Oral drug delivey, Sustained drug release.


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