EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF EXTRACT OF ERYTHROPHLEUM IVORENSE STEM BARK IN EXPERIMENTAL ANIMALS
Wakeel O.K*, Ayankunle A.A, Olapade M.K, Aderibigbe A.A
ABSTRACT
Erythrophluem ivorense is a medicinal herb used in Africa to treat ailments such as convulsion, swellings, pain
and emesis. Anti-nociceptive and anti-inflammatory activities of the crude methanol extract of Erythrophluem
ivorense were investigated using experimental pain models, including thermal nociception like hot plate test and
chemical nociception induced by intraperitoneal acetic acid or subplantar formalin injection in vivo. The antiinflammatory
property of the extract were studied using systemic administration in carrageenan-induced paw
oedema. The CME administered intraperitoneally significantly (P< 0.5) reduced the number of abdominal
constrictions by 25.8, 83.7, 88.7% at a dose of 5, 10, 20mg/kg respectively. The CME increased the reaction time
on a hot plate at doses of 5, 20, 20mg/kg by 3.6±0.40, 5.8±0.32, 7.0±0.50 respectively in dose related manner.
CME reduced (42.5±0.25, 38.2±0.50 and 35.6±0.40) the paw licking time at doses of 5, 10, 20mg/kg i.p and
(116.1±0.05 and 67.0±0.35) at doses 10 and 20mg/kg in both phases respectively. CME at doses of 5, 10, 20mg/kg
inhibited paw oedema sized by 25.0, 41.7, 58.3% after application of carrageenan respectively. The study revealed that crude methanol extract (CME) of Erythrophluem ivorense stem bark contains components with antinociceptive
and anti-inflammatory properties.
Keywords: Erythrophleum ivorense, Anti-inflammation, Analgesic, Formalin test, Hot plate.
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