Abstract
EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF EXTRACT OF ERYTHROPHLEUM IVORENSE STEM BARK IN EXPERIMENTAL ANIMALS

Wakeel O.K*, Ayankunle A.A, Olapade M.K, Aderibigbe A.A

ABSTRACT

Erythrophluem ivorense is a medicinal herb used in Africa to treat ailments such as convulsion, swellings, pain and emesis. Anti-nociceptive and anti-inflammatory activities of the crude methanol extract of Erythrophluem ivorense were investigated using experimental pain models, including thermal nociception like hot plate test and chemical nociception induced by intraperitoneal acetic acid or subplantar formalin injection in vivo. The antiinflammatory property of the extract were studied using systemic administration in carrageenan-induced paw oedema. The CME administered intraperitoneally significantly (P< 0.5) reduced the number of abdominal constrictions by 25.8, 83.7, 88.7% at a dose of 5, 10, 20mg/kg respectively. The CME increased the reaction time on a hot plate at doses of 5, 20, 20mg/kg by 3.6±0.40, 5.8±0.32, 7.0±0.50 respectively in dose related manner. CME reduced (42.5±0.25, 38.2±0.50 and 35.6±0.40) the paw licking time at doses of 5, 10, 20mg/kg i.p and (116.1±0.05 and 67.0±0.35) at doses 10 and 20mg/kg in both phases respectively. CME at doses of 5, 10, 20mg/kg inhibited paw oedema sized by 25.0, 41.7, 58.3% after application of carrageenan respectively. The study revealed that crude methanol extract (CME) of Erythrophluem ivorense stem bark contains components with antinociceptive and anti-inflammatory properties.

Keywords: Erythrophleum ivorense, Anti-inflammation, Analgesic, Formalin test, Hot plate.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT