European Journal of Biomedical and Pharmaceutical Sciences

SCHIFF BASES AS ANTI-INFLAMMATORY AGENTS - A COMPREHENSIVE REVIEW

Shallu Sachdeva* and Swati Agrawal

ABSTRACT

Organic chelating ligands can form a large number of complexes with metal ions, which imparts the complexes academic, commercial and medicinal importance.[1] As a result, their study attracts chemists in the world. Bioinorganic chemistry involving presence of metal ions in the biological system and their importance, organometallic chemistry and biomedical sciences are the fields of study gaining continuous importance as a result of this. Schiff bases along with their various derivatives belong to the category of these organic chelating ligands. The formation of Schiff bases is a result of reaction between a primary amine and an aldehyde or a ketone. They are considered as imines(C=N). Metal ion complexes of Schiff bases and their derivatives have been studied for a number of biological activities including antimicrobial, antifungal, antitumor, antianxiety and anti-inflammatory. This review focusses on the anti-inflammatory activity of metal ion -Schiff base complexes and their various derivatives and also focusses on the need to prepare new derivatives of Schiff bases with various metal ions and organic chelating ligands.

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