European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL N-MANNICH BASES OF BENZIMIDAZOLE DERIVATIVES

Vinod Malviya*, Balkrishana Dubey and Deepak Basedia

ABSTRACT

The current interest in the development of new antimicrobial chemotherapy has been the mainstay of medicinal intervention against infectious diseases caused by various pathogens. A matter of concern in the treatment of microbial infections is the limited number of efficacious antimicrobial drugs. There is a real perceived need for the discovery of new compounds that are endowed with antimicrobial activities, possibly acting through mechanism of action, to which many clinically relevant pathogens are now resistant. In order to expand the group of benzimidazole derivatives, we synthesized several new benzimidazole ring containing N-mannich bases. It has been observed that the presence of two (or) more heterocyclic moieties fused or linked enhance the biological profile of drug molecules by many folds. We reported our results from a study of replacing the N-1 hydrogen of novel benzimidazole derivatives with different types of substitutions like sulphanilamide and piperazine to form N-methyl substituted benzimidazole derivatives by mannich reaction. The structure of the synthesized compounds were elucidated by physical and spectral (UV, IR, 1H NMR and Mass) analysis.

Keywords: Benzimidazole derivative, Mannich base, O-phenylene diamine, Propionic acid, Acetic acid, Butyric acid.