European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF OSMOTICALLY CONTROLLED BILAYER TABLET OF FUROSEMIDE

Mahesh B. Kshirsagar* and Vishal R. Rasve

ABSTRACT

The current research work study deals with the development of Osmotically Controlled Bilayer Tablet of Furosemide. The aim & objective of research work was to improve the bioavailability & half-life of Furosemide drug by using push pull method using various polymers such as Carbopol 934P & PVP k30. To study the effect of varying concentration of control release agent (polymer) in both Drug layer and Push layer. The venlafaxine Hcl is an Anti-diuretic and anti-hypertensive gives short eliminations half-life of 1-3 hr. Furosemide is absorbed from the gastrointestinal tract. It displays variable bioavailability form oral dosage from ranging from 10-90%. Metabolism of furosemide occurs mainly in the kidneys and the liver to a smaller extent. The kidneys are responsible for 85 % of total Furosemide clearance the elimination half-life up to 100min. Furosemide osmatic tablets given orally administrated gets a good first pass effect. The bioavailability is 10-90 %. The preparation of osmotic tablets was characterized for % yield, % drug content, %, bulk density, tapped density, Housner‟s ratio, carr‟s index, Angle of repose, in-vitro drug release (%CDR) for anti – diuretic activity. The FTIR shows the detect the functional group in Furosemide active drug. The UV analysis of Furosemide shows absorbance at 269 nm. In that release kinetics the korsemeyer peppas model is best fir model for prepared osmotic tablets. The results give prepared osmotic tablet enhanced drug content, bulk density, tapped density, Housner‟s ratio, carr‟s index, Angle of repose. In the optimized F4 (Carbopol 934P +drug) trial which release Furosemide 16.9±1.2 % in 1st hr. & remaining drug released upto12 hrs. which is 96.2 ±2.45%. The Osmotic Tablets were found to be stable under stability condition, which that the better drug delivery system (ODDS) & Novel drug delivery system for improved therapeutic effect of anti-diuretic as well as anti-hypertensive drug Furosemide.

Keywords: Controlled Release, Furosemide, Polymers, anti-diuretic, Osmotic tablets, anti-hypertensive, In- Vitro drug release.