European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF EFFECT OF DOXORUBICIN AND NATURAL ANTIOXIDANTS VITAMIN E, A SEPERATELY AND COMBINATION ON SELECTED ANTIOXIDANT ENZYME LEVELS OF ALBINO RAT – KIDNEY TISSUE

B. Vijayudu*, K. Harish Babu, A. Venkata Mohan Naidu, K. Kalandar basha and C. Venkata Sriram

ABSTRACT

The present study investigated the in vivo effects of 20 mg/kg wt of Doxorubicin and 80 mg/kg wt of Vitamin E, 40 IU/kg wt of Vitamin A separately and in combination over 10 weeks (weekly doses) on Kidney antioxidant enzyme activity levels in rats. After 10 weeks the activities of Superoxide dismutase, Catalase, Glutathione reductase, Glutathione-S-transferase, Glutathione peroxidase and the levels of Lipid peroxides and reduced Glutathione were presented. The data indicated a significant decrease the few parameters and few parameters increases are studied under Doxorubicin stress. Doxorubicin altered parameters were significantly reversed by vitamin E plus Doxorubicin, Vitamin A plus doxorubicin also significantly reversed the Doxorubicin altered parameters. From the results it is reported that Doxorubicin impairs overall antioxidant enzyme activities and the antioxidants like vitamin E and vitamin A by their antioxidant mechanism might be neutralizing the Doxorubicin altered antioxidants in vivo.

Keywords: Doxorubicin, Vitamin E, Vitamin A, Antioxidant enzymes, Kidney tissue.