European Journal of Biomedical and Pharmaceutical Sciences

LIPID NANOPARTICLES FOR MODULATION OF UV RADIATION: INFLUENCE OF COMPOSITION AND PRODUCTION TECHNOLOGY

Elisânia Fontes Silveira, Kahynna Loureiro, Amanda de Sousa Feitosa, Luciana Nalone Andrade, Eliana B. Souto, Patrícia Severino*

ABSTRACT

The aim of this work was to compare in vitro photoprotection effect of benzophenone-3 (BZN) loaded in three distinct lipid nanocarriers, namely, elastic liposomes, solid lipid nanoparticles (SLN) and nanostructured Lipid Carriers (NLC). Lipossomes were produced by Bangham method and SLN/NLC by solvent diffusion method. All formulations were characterized by mean particle size, polydispersity index (PI), zeta potential (ZP), encapsulation efficiency (EE), and in vitro photoprotection capacity. The size of lipid nanoparticle range 100 to 800 nm and the polydispersity index range 0.2 to 0.8. The zeta potential range to -9 a -36 mV and encapsulation efficiency was 18 to 100 %. UV protection in vitro essays showed increase UV absorption over the time. Conclusion, it was observed type of matrix lipid influence in UV photoprotection. Solid matriz showed more promising results compared liposome.

Keywords: sunscreen, lipid nanoparticle, solar radiation, solid lipid nanoparticle, nanostructured lipid carrier and liposome.