European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON: VESICULAR DRUG DELIVERY SYSTEM FOR LIVER TARGETING

Shiv Shankar*, Harsh Shrivastav, Vishnu Mishra, Adarsh Mishra, Aman Kasaudhan, Vishal Gaud and Govind Mishra

ABSTRACT

Liver diseases are mainly caused by either toxic chemical (certain antibiotics, peroxides oil, aflatoxin, carbon tetrachloride chlorinated hydrocarbons etc), excess consumption of alcohol, infections or autoimmune disorder. Liver has an essential role in the regulation of physiological process. It is involved in several vital functions such as storage, secretion, metabolism and detoxification of a variety of drugs and xenobiotics. The conventional drugs have short residence time at the site of application and poor bioavailability which leads to incomplete elimination of organisms causing reoccurrence and tolerance. Recently, vesicular mode of delivery of drugs has gained attraction because of its improved therapeutic efficacy and stability. Vesicles are bilayered structures formed by hydration of lipid molecules and can be used for incorporating both hydrophilic and lipophilic drugs.

Keywords: Liver diseases, Liposomes, Phytosomes, Ethosomes.