European Journal of Biomedical and Pharmaceutical Sciences

HEMATOLOGICAL AND DEMOGRAPHIC PROFILE IN PATIENTS WITH BCR-ABL TRANSCRIPTS POSITIVE CHRONIC MYELOID LEUKEMIA IN A TERTIARY CARE HOSPITAL, BANGLADESH.

Dr. Sanjida Khondakar Setu* and Dr. Abu Naser Ibne Sattar

ABSTRACT

Background: Chronic Myeloid Leukemia (CML) with BCR-ABL positivity is one of the most common genetic abnormalities among blood neoplasm that usually requires regular blood examination to diagnose. If detected early, it has a high cure rate. This study aims to assess the hematological and demographic profile among BCR-ABL (p210) transcripts positive CML patients in a tertiary care hospital, Dhaka, Bangladesh. Methods: Forty-five CML patients who came to Microbiology and Immunology department, Bangabandhu Sheikh Mujib Medical University and detected as BCR-ABL positive cases were enrolled in this study. Results: Among forty-five BCR-ABL (p210 kDa) positive CML patients, most common age group affected was between 35-44 years. Hemoglobin value ranged from 12.2 g/dL to 16.9 g/dL with a mean value of 10.44 ± 2.48g/dL. Most of the patients (57.79%) had a hemoglobin level between 7 g/dL to 11 g/dL. Most of the patients (48.89%) had their leukocyte count >100×109/L. Platelet count ranged from 16×109/L to 2100×109/L with a mean value of 409.13 ± 380.52×109/L. Conclusion: Unlike the western countries, Chronic Myeloid Leukemia more prevalent in young age group in Bangladesh. Chronic myeloid leukemia patients displayed variable hematological presentation.

Keywords: Chronic myeloid leukemia, p210 kDa, Bangladesh.