European Journal of Biomedical and Pharmaceutical Sciences

SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL Tl(I)-15C5 COMPLEXES

Rajeev Ranjan*

ABSTRACT

Crown ethers are being used in applications across the spectrum of science. Beyond their traditional place in chemistry their applications in biology include the ability to regulate enzyme activity, interact with and cleave DNA, and act as antimicrobial agents. Functionalized crowns have been synthetically designed to achieve these functions; however, the basic heterocycles themselves yield beneficial biological interactions as well. Simple crown compounds such as 15C5 and 18C6 have the ability to interact with enzymes. Remarkable complexation properties of cryptand have been found towards heavy metal cations like Tl+, Cd2+, Hg2+, Pb2+ etc. The crown ether-metal ion binding is enhanced in the absence of non-coplanar donor oxygen atoms and electron withdrawing substituents in the crown ether skeleton. The present paper describes the preparation, spectral characterization, antibacterial and antifungal studies of novel Tl(I)-15C5 complexes. The metal salts used for complexation were salts of nitrophenols. Products were isolated from thallium salts of all the three ligands, o-nitrophenol, 2,4-dinitrophenol and 2,4,6-trinitrophenol. The bonding patterns of complexes are suggested from the studies of elemental analysis, molar conductivity, IR, UV-Vis and 1H-NMR spectral analysis. Antibacterial and antifungal activities of the synthesized complexes were measured by Kirby Bauer disc diffusion method.

Keywords: 15C5, FTIR, NMR, ONPH, DNPH, TNPH.