European Journal of Biomedical and Pharmaceutical Sciences

SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL TL(I)-18C6/DB18C6 COMPLEXES

Rajeev Ranjan*

ABSTRACT

The affinity of crown ethers for a metal ion is strongly dependent on the size of the ring of the crown ether. The crown ether-metal ion binding is enhanced in the absence of non-coplanar donor oxygen atoms and electron withdrawing substituents in the crown ether skeleton. The present paper describes preparation, spectral characterization and antimicrobial studies of novel Tl(I)-18C6/db18C6 complexes. The metal salts used for complexation were salts of nitrophenols. Products were isolated from thallium salts of all the three monoionic ligands, 2-nitrophenol, 2,4-dinitrophenol and 2,4,6-trinitrophenol. The bonding patterns of complexes were suggested from the studies of elemental analysis, molar conductivity, FTIR, UV-Vis and 1H-NMR spectral analysis. Antibacterial and antifungal activities of the synthesized complexes were measured by Kirby Bauer disc diffusion method.

Keywords: 18C6, DB18C6, ONPH, DNPH, TNPH.