European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND EVALUATION OF L-ARGININE CEFATOXIME PESSARY (ALCECO®) (Part I)

Mohanad A. Al-Bayati*, Hashim Whaib and Ferial Mahdi

ABSTRACT

Aim of our present study was to formulate the L-arginine Cefatoxime pessary (Alceco®) by using direct compression of the formulation technique to improve the physical, chemical and pharmaceutical properties of pessary. We were used the L-arginine Cefatoxime as a core drug preparation, as a vaginal tablet shape suitable in applicators it has a display swelling index slightly decrease as compared with pre storage time for 14 hours. On the other hand pre and post storage period were not displayed differences in solubility, So no changes were seen in cumulative release L-arginine during storage period as compared with pre stability study period and L-arginine viability. Finally stability of their properties programed really sophisticated in as vaginal application. The project and right pharmaceutic product was sponsored by ministry of higher education and scientific research; research and development department.

Keywords: L-arginine, Cefatoxime, Pessary, ALCECO, Swelling index, Vagina, ewe.