Abstract
EFFECT OF CALCIUM CARBIDE ON TESTIS OF WISTAR ALBINO RATS

Dr. Gita Yadav*, Dr. Shamsher Shrestha, Dr. Prabhakar Yadav, Dr. Churamani Pokhrel

ABSTRACT

Introduction: Calcium carbide is commonly used as artificial fruit ripening agent. Once CaC2 comes in contact with moisture it releases acetylene gas (Carbide gas) which acts similar to the fruit ripening agent ethylene. Ingestion of acetylene produces radicals which initiate detrimental effects on various organs including all the human system. Aims & Objectives: To investigate the effect of calcium carbide on testis via evaluation of gross and histological changes. Materials and Methods: Twenty four male healthy wistar albino rats weighing 130-200gm were randomly divided into 4 groups i.e. control group (received normal diet) and group I (normal diet mixed with 0.5gm CaC2), group II (received normal diet mixed with 0.25gm CaC2), group III (normal diet mixed with 0.125gm CaC2). Each group consisting of 6 rats. All groups were treated over a period of consecutive 21 days. On 22nd day all rats were anesthetized by inhalation of ether and scarified by cervical dislocation. Testis were removed and preserved in 10% formalin solution for histological examination. One way ANOVA was used for data analysis at 95% confidence interval .The experiment was carried out at the animal house of department of Human Anatomy. Results: CaC2 had no effect on body weight of rats. The weight of rats was increased in all groups. For weight of testis as compared to control group (mean± SD = 1.12 ± .07) the weight of group I (mean± SD = .54 ± .10) decreased but in group II (mean± SD = 1.18 ± .12) and in group III (mean± SD = 1.16 ± .03) there were no as such effect. Histological study of testis showed decrease in diameter of seminiferous tubules of group I (mean± SD = 62.89 ± 14.07) as compared to control group (mean± SD = 105.77 ± 8.69) but no effect on group II (mean± SD = 104.00 ± 5.99) and group III (mean± SD = 114.84 ± 15.37). Conclusion: Calcium carbide caused both morphological and histological changes in testis of wistar albino rats.

Keywords: Calcium carbide, acetylene, testis, light microscopy and histology.


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