European Journal of Biomedical and Pharmaceutical Sciences

CLINICAL FACTORS AFFECTING SEIZURE OCCURRENCE FOLLOWING INTRACRANIAL MENINGIOMA SURGERY

Sushil Mohan Bhattarai*, Subodh Gautam, Rupesh Raut, Rajiv Jha and Prakash Bista

ABSTRACT

Background: Seizures are commonly associated with Intracranial meningiomas. The outcome of meningioma surgery is good, however, the burden of postoperative seizures and its impact on quality of life are very debilitating to the patient. This study aims to analyze the factors that are associated with post-operative seizures in intracranial meningioma. Methodology: Data from a prospective non-randomized sample of patients with the diagnosis of intracranial meningioma admitted for surgery in the Neurosurgery department of a referral center were collected. Demographic data and information regarding clinical, radiological, surgical, and pathological factors were recorded at admission and subsequently during management. The patients were followed up for outcome and occurrence of seizure for 1 month. Results: A total of 35 cases were included in the study. The majority of patients had good outcomes following surgery (85% had GOS 5 at 1 month). The incidence of postoperative seizure was 30.6%. Multivariate analysis was done and it was observed that alcohol consumption (p-value - 0.001) and requirement of postoperative ventilation (p-value - 0.004) were factors significantly associated with the occurrence of postoperative seizures. Conclusion: The overall outcome of meningioma surgery at this center is good. The high incidence of postoperative seizure and its association with perioperative factors like the requirement of postoperative ventilation is an important marker for the prediction of seizures. Given the impact of seizures on quality of life in benign diseases like meningioma, more studies with longer follow up need to be done to further illustrate the factors.

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