Abstract
INSILICO STUDY OF BINDING PROFILES EVOLUTION OF PEDALIUM MUREX LINN COMPOUNDS TOWARDS HUMAN IMMUNO VIRUS (HIV)

Muthu Murugan* and Dr. P. Nirmala

ABSTRACT

AIDS (Acquired Immune Deficiency Syndrome), a pandemic disease caused by Human Immuno Deficiency virus (HIV), are pointed out a life threatening virus all over the world. Though there is a considerable research to minimize the mortality rate caused by HIV, but the therapies are limited to the target action, this laid a path to find out the effective target and promising lead to overcome this issue. Using Insilico based molecular docking approach to minimize the effect, the C-C chemokine receptor type (CXCR) is an important target for HIV infection was selected to plot the interaction towards PEDALIUM MUREX LINN based compounds through ligand fit module of Accerlys Discovery studio. The compounds 9, 12-octadecadeionic acid, 9-octadecenoic acid have been identified as inhibitors for CXCR, CCR5, gp 120 and gp 41 receptors. It’s indicated these two compounds might be considered as a potential lead molecule against selected receptors for HIV infection. Further studies need to be carried out to evaluate the pharmacological efficacy of these inhibitors.

Keywords: HIV, Molecular docking, CXCR, Ligand fit.


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