FORMULATION AND EVALUATION OF ATENELOL LIQUID FILL FORMULATIONS FOR SOFT GELS
Sowmya Maddukuri*, Devineni Jyothirmayee, Sobitha Rani Pedireddi and Udaya Chandrika Pulla
ABSTRACT
The present investigation was under taken with the objective of enhancing the permeability of Atenolol (ATL), a β1 selective receptor antagonist through the preparation of liquid fill formulations for soft gels. Liquid fill formulations for ATL(25mg) soft gels were prepared using excipients such as dimethyl sulfoxide(DMSO), Ethanol, hydrophilic vehicles like Propylene glycol (PG), polyethylene glycol(PEG-400) and HP-β-CD, Water. The prepared formulations were evaluated for Appearance, pH, content uniformity, viscosity, drug excipient compatibility and in vitro drug release parameters. Stability of the optimised formulation was evaluated by storing for six months, at 400C and 75% RH. Among all the prepared formulations, formulation F3 containing 40% DMSO, 23.75% PEG-400 and 23.75% PG showed superior drug release (100% within 75sec) with definite physical and chemical stability. The results provide surveillance for developing soft gel capsule of ATL that give better rate of absorption, than existing dosage form and provide quick onset of action with better patient compliance.
Keywords: Atenolol, In vitro dissolution, Liquid fill formulations, Stability, Viscosity.
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