R. Saitejaswi*, S. Swapna, Dr. A. Madhu Babu and Dr. Vasudha Bakshi


Objective: Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. Various new technologies have been developed for the transdermal delivery of some important drugs. The goal of the present study was to formulate and evaluate the potential use of transfersomal vesicles as a transdermal drug delivery system for poorly soluble drug, Lornoxicam. Methods: It was investigated by encapsulating the drug in various transfersomal formulations composed of various ratios of different spans (80,60,40) and tween-80 prepared by thin film hydration method. The prepared formulations were characterized for entrapment efficiency (EE%), drug content, In vitro drug release studies through a cellophane membrane and stability studies. Results: The vesicles were spherical in structure as confirmed by Transmission Electron Microscopy. The EE% of Lornoxicam in the vesicles was in the range of 82.84 to 89.85 %. The result revealed that Lornoxicam in all of the formulations was successfully entrapped with uniform drug content. Transfersomal gel containing 20mg of the drug and 20% of span 80 was concluded as the optimized formulation (F6), as it showed maximum drug entrapment (89.84%) and cumulative percent drug release .5 ). Further stability studies were carried out at 5 C for a period of weeks. Conclusion: It is evident from this study that transfersomes are a promising prolonged delivery system for Lornoxicam and have reasonably good stability characteristics. This research suggests that Lornoxicam loaded transfersomes can be potentially used as a transdermal drug delivery system.

Keywords: Lornoxicam, Transfersomes, Transdermal drug delivery, Spans and Tweens.

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