FORMULATION AND EVALUATION OF LORNOXICAM LOADED TRANSFERSOME GEL
R. Saitejaswi*, S. Swapna, Dr. A. Madhu Babu and Dr. Vasudha Bakshi
ABSTRACT
Objective: Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully
achieve its potential as an alternative to oral delivery and hypodermic injections. Various new technologies have
been developed for the transdermal delivery of some important drugs. The goal of the present study was to
formulate and evaluate the potential use of transfersomal vesicles as a transdermal drug delivery system for poorly
soluble drug, Lornoxicam. Methods: It was investigated by encapsulating the drug in various transfersomal
formulations composed of various ratios of different spans (80,60,40) and tween-80 prepared by thin film
hydration method. The prepared formulations were characterized for entrapment efficiency (EE%), drug content,
In vitro drug release studies through a cellophane membrane and stability studies. Results: The vesicles were
spherical in structure as confirmed by Transmission Electron Microscopy. The EE% of Lornoxicam in the vesicles
was in the range of 82.84 to 89.85 %. The result revealed that Lornoxicam in all of the formulations was
successfully entrapped with uniform drug content. Transfersomal gel containing 20mg of the drug and 20% of
span 80 was concluded as the optimized formulation (F6), as it showed maximum drug entrapment (89.84%) and
cumulative percent drug release .5 ). Further stability studies were carried out at 5 C for a period of
weeks. Conclusion: It is evident from this study that transfersomes are a promising prolonged delivery system for Lornoxicam and have reasonably good stability characteristics. This research suggests that Lornoxicam loaded transfersomes can be potentially used as a transdermal drug delivery system.
Keywords: Lornoxicam, Transfersomes, Transdermal drug delivery, Spans and Tweens.
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