Abstract
THE RELATIONSHIP OF INTRAVITREAL BEVACIZUMAB INJECTION AND POSTERIOR CAPSULE RUPTURE IN DIABETIC PATIENTS UNDERGOING PHACOEMULSIFICATION CATARACT SURGERY

*Nasser A. Fugara MD., Mohd. Y. Alhashki MD., Shehab A. Al-Abed MD., Omar A. Alsaqour MD. and
Laith T. Al-Khateeb MD.

ABSTRACT

Objectives: To investigate the relationship between intravitreal Bevacizumab injection and posterior capsular rupture in diabetic patients who underwent phacoemulsification cataract surgery at King Hussein Medical Center of the Royal Medical Services. Patients and methods: A retrospective comparative study for diabetic patients who underwent phacoemulsification cataract surgery at King Hussein Medical Center during the period between December 2021 and December 2022. Patients were divided into two groups. Group1 included patients who had previous intravitreal bevacizumab injection and group2 included patients who did not receive any injection. The number of intravitreal bevacizumab injections in first group was also recorded. Posterior capsular rupture occurrence in both groups was compared. Also the number of injections was recorded in order to investigate whether the incidence of posterior capsule rupture has relation with the number of injections. Results: The total number of patients in group 1 was 412 patients in group 1 and 378 in group 2. Among patients in group 1, 42 patients had one injection, 86 patients had two injections and 284 patients had three or more injections. Posterior capsular rupture occurred in 18 patients in group 1 compared to 4 patients in group 2. Fourteen patients of those in group 1 who developed posterior capsular rupture received three or more injection representing 77.8% of them. Conclusion: The risk of posterior capsular rupture in diabetic patients undergoing phacoemulsification cataract surgery increases after intravitreal Bevacizumab injection especially in those who received three or more injections.

Keywords: Posterior capsular rupture, intravitreal Bevacizumab, cataract, diabetes.


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