Abstract
USE OF BROMOTHYMOL BLUE AS CHROMOGENIC REAGENT FOR THE COLORIMETRIC DETERMINATION & VALIDATION OF COBICISTAT IN ITS BULK FORM

Chandni Saha*, Kolukula Sindhu, Brungi Harika, Gundala Sukanya, Manasa

ABSTRACT

Cobicistat a CYP3A inhibitor, indicated to increase systemic exposure of Atazanavir, Darunavir or Elvitegravir in combination with other antiretroviral agents in the treatment of HIV-1 infection. It is only a pharmacokinetic enhancer, but has no antiviral activity. The review of literature reveals not much spectrophotometric work being carried out for its estimation & hence with the need to explore, in the present work a colorimetric method was developed for its estimation in bulk form based on the principle of ion-pair complex using Bromothymol blue as chromogenic reagent. The method developed was observed to have absorption maxima at 411mn, linear (r=0.999) over the range 10 – 50ug/ml, precise and robust (%RSD). Thus this validated method can be used for the determination of Cobicistat.

Keywords: Cobicistat; Colorimetric method development; Bromothymol blue.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT