European Journal of Biomedical and Pharmaceutical Sciences

APPLICATION OF PAPAYA LEAF AND HONEY EXTRACT ANALGESIC TESTS IN MALE MICE TO REDUCE MENSTEM PAIN IN ADOLESCENTS IN THE NGAWEN II PUSKESMAS AREA, GUNUNG KIDUL DISTRICT

K. H. Endah Widhiastuti, Sih Rini Handajani, Wiwik Setyaningsih and Rustam Aji*

ABSTRACT

Background: Menstruation Complaints of menstrual pain can occur ranging from mild to severe complaints Menstrual pain can be treated with pharmacological and non-pharmacological therapy. One of the traditional methods made from natural ingredients that are used as medicine to reduce pain during menstruation, namely papaya leaves (carica papaya) and honey, many papaya tree plants grow around us. Papaya leaves contain vitamin E which can reduce menstrual pain. Honey contains glucose and fructose, which function to control the smooth muscles of the uterus, so that the uterine muscles can relax, so there will be a reduction in pain during menstruation. Research objective: To test the effectiveness of the analgesic reaction of honey and papaya leaves. Research Methods: This study used the Experiment method with a post test design only approach conducted at the Pharmacy Laboratory of Gajah Mada University, Yogyakarta. Healthy male white mice as experimental animals. A total of 25 male Wistar mice were divided into 5 groups to test the effectiveness of analgesics on papaya leaves and 5 groups to test the effectiveness of honey analgesics. Data processing was carried out by one way Anova statistical test. Results: The optimal analgesic effect can be shown by the less amount of writhing at the intervals observed, namely per 10 minutes (stretching inhibition 48.83%) and still persists at 60 minutes (stretching inhibition 75.79%). Post hoc KVII (3 mg/0.125 mL papaya leaf extract suspension and 56.7 mg/20 gram rat body weight (25:75)) proved significantly different from KIV (honey 75.6 mg/20 gram rat body weight). KVII when compared to KIV is much better able to provide pain protection in the form of decreased writhing in mice because judging from the % inhibition of KVII stretching it is much higher. Conclusion: The combination of papaya leaf decoction and honey has a higher effect than honey and papaya leaf decoction. Keywords: papaya leaf, honey, menstrual pain, young women.

Keywords: Knowledge, attitude and ovitrap.