Abstract
RECENT ADVANCES IN ANTICANCER PROFILE OF ISATIN AND DERIVATIVES

Ramesh Kumar*

ABSTRACT

Isatin (1H-indole-2, 3-dione) and its analogues are important class of heterocyclic compounds that can be used as precursors for drug synthesis. Isatin is an indole nucleus substituted with carbonyl groups at 2nd and 3rd position. Chemically it can be modified in to different compounds such as Schiff bases, mannich bases, thiosemicarbazones, spiro compounds. Besides, in numerous analogues it is clubbed with another heterocyclic moiety to give the active agents. It is nucleus possessing versatile activity such as antimicrobial, anticancer, antifungal, anti-malarial, antiviral and anti-tubercular. Today cancer is the second most dreadful disease after cardiovascular disease. Many pharmacophore have the potential as anticancer agent Therefore, keeping in mind the anticancer potential of isatin and derivatives, important anticancer research has been gathered in this review.

Keywords: Isatin, 1H-indole-2, 3-dione, anticancer.


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