Abstract
EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF STEMS OF HIBISCUS PLATANIFOLIUS IN ALLOXAN INDUCED DIABETIC RATS

H.G Raghavendra*, P.Sahasreddy, G.Lakshmikanth, A. Manohar, A.M.Venumadhavi, K.Rani

ABSTRACT

The hypoglycemic effect of ethanolic extract of stems of Hibiscus plantanifolius was evaluated in alloxan - induced diabetic rats. Oral administration of extract (250, 500 /kg bw) for 28 days resulted in a significant reduction in blood glucose level. The effect was compared with 0.5gm/kg of glibenclamide (i.p). Alloxan induced hyperglycemia rat models were used for the evaluation of anti-diabetic activity. The effect of ethanolic extract of stems of Hibiscus plantanifolius of normal glycemic, Alloxan induced hyperglycemic activity were showed in dose dependant manner. The present study was design to evaluate ethanolic extract of stems of Hibiscus plantanifolius 250 mg/kg and 500 mg/kg p.o dose against Diabetic in rats. It was evaluated by Physical parameter like Body weight, and Biochemical Estimations by Serum parameters: glucose, triglycerides, cholesterol, HDL, LDL levels.

Keywords: Antidiabetic activity, alloxan, Glibenclamide, Hibiscus plantanifolius.


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