Abstract
FORMULATION, DEVELOPMENT AND BIOAVAILABILITY PROFILING OF ILLICIUM VERUM (METHANOLIC FRACTION)

Saba Karim*, Rajesh Singh Pawar, Archana Bagre and Anand Gaurav

ABSTRACT

The Illicium verum is an evergreen Chinese plant, from which a culinary spice named star anise is obtained and is predominantly used in Asian countries. Besides its flavor, it possesses high medicinal value. The present study was carried out to extract, phytochemical investigation, quantitative analysis, formulate and evaluate an herbal suspension containing Illicium verum. The total seven herbal suspension formulations were prepared by trituration method and evaluated for physical test, sedimentation volume, redispersibility, flow rate, viscosity, pH and particle size. The result of all the formulations were found to be in the range and F5 formulation showed sedimentation volume of 1.20 ml, redispersibility in 1 inversion, flow rate of 5ml/ 1 min 16 sec, viscosity of 274cP, pH of 6.67 and particle size is 20μm. All the formulations then subjected to in-vitro drug release studies. In-vitro bioavailability assessment of the suspension was performed by dialysis bag diffusion method in 7.4 pH phosphate buffer. F5 formulation released its 95 % drug in 15 minutes. Hence, the F5 formulation released the maximum drug in 15 minutes so that the bioavailability of the formulation will also be good. The in vitro drug release data of the optimized formulation F5 was subjected to goodness of fit test by linear regression analysis according to zero order, first order kinetic equation and Higuchi’s models in order to determine the mechanism of drug release. When the regression coefficient values of were compared, it was observed that ‘r’ values of zero order was maximum i.e. 0.999 hence indicating drug release from formulations was found to follow zero order models kinetics. Stability study of the formulation F5 was performed for 3 months and for three different conditions like 8°C± 5°Cand 40% RH, 25°C± 5°Cand 40% RH and 40°C± 5°C and 70% RH and the result showed that herbal formulation is stable.

Keywords: Illicium verum, Phytochemical investigation, Quantitative analysis, Herbal suspension, Trituration method, Bioavailability profiling.


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