Abstract
FORMULATION AND EVALUATION OF ANTIFUNGAL DRUG BASED TOPICAL DOSAGE FORM FOR THE MANAGEMENT OF CONTACT DERMATITIS

Avinash Singh*, Niharika Thakur and Anand Gaurav

ABSTRACT

Skin tissue is frequently exposed to various irritant substances in the workplace, particularly in wet work, which can lead to the development of occupational contact dermatitis. In contact dermatitis the inflammation is accompanied by the secondary infections caused by the invasion of the bacteria viz. staphylococcus aureus. This very condition leads to secondarily infected dermatoses which requires immediate intervention to cure the infection by the application of the antibacterial agents in such a way that the skin to eliminate the bacteria from the site of infection. The objective of the present study was to formulate cream of terbinafine hydrochloride and evaluating their organoleptic characteristics, spreadability, pH values, viscosity measurement and in-vitro drug release. Among all, the formulation F4 was found to be best formulation. The spreadability, pH and viscosity of F4 formulation were found to be 13.86 g.cm/s, 7.46 and386±0.36 cps respectively and Invitro drug release was found to be 94.16 at 24 hrs which was significantly high when compared to other formulation. The prepared cream containing terbinafine hydrochloride was optimized and can be use for topical preparation for its antifungal affect. The results were obtained which showed that cream was a promising candidate for transdermal delivery with targeted and prolonged release of a drug. It also enhances skin permeation of many drugs.

Keywords: Contact dermatitis, Staphylococcus aureus, Cream, Terbinafine hydrochloride, Organoleptic characteristics.


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