Abstract
ROLE OF ANTI-MULLERIAN HORMONE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME ON METFORMIN THERAPY.

Dr. Roya Rozati, Dr. Surayya Tahseen*, Dr. Akhila Reddy, Dr. Nazima Allaudin, Dr. FatimaTahniyath, Dr. Fatima Hafeez4 and Ayyapathi Mehdi Gautam

ABSTRACT

Background: AMH production by granulosa cells in the polycystic ovary is 2-3 fold increase compared to healthy women. Purpose of the study: Anti-Mullerian hormone (AMH) is produced by the granulosa cells surrounding prenatal and antral follicles and has an important role in the development and maturation of follicles. Several studies have suggested that AMH serum levels may be a marker for polycystic ovary syndrome (PCOS). Methods: Prospective study was conducted in the Department of Obstetrics and Gynaecology, Owaisi Hospital and Research Centre and Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad from March 2014- April 2015. Results: A total of 34 patients diagnosed cases of PCOS. Mean serum Anti Mullerian hormone levels were significantly decreased in PCOS population on metformin therapy as compared to PCOS population not on metformin therapy. Conclusion : Serum AMH is a useful prognostic biochemical marker for metformin therapy in PCOS .

Keywords: granulosa, Anti-Mullerian, antral follicles.


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