Abstract
FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF RIFAMPICIN LIPOSOME FORMULATIONS

Shaik Sharif, V. Jhansi Priya Marabathuni*, Naidu Narapusetty

ABSTRACT

Rifampicin liposomes (F) were prepared by solvent injection method using different ratios of soya lecithin and Cholesterol. Characterization of liposomes was done by using optical microscopy, scanning electron microscopy and particle size distribution. Evaluation for liposomes are done by drug entrapment efficiency, in vitro diffusion studies, ex vivo diffusion studies, statistical analysis, optimization, validation of the experimental design. Stability studies were done for liposomes on storage at 2-8 °C and room temperature. From the results of physicochemical parameters, rifampicin liposomal dispersion F-8 was selected as optimized formulation. Further F-8 was formulated into pharmaceutical pastilles dosage forms for buccal drug delivery. Evaluation for FP-8 was done by average weight, drug content, swelling, erosion, moisture absorption, pH, bio adhesion time, bio adhesive strength, in vitro drug release, stability studies and in vivo pharmacokinetic studies using rabbit model. Rifampicin liposomal pastilles FP-8 are uniform in size, flexible and found to have uniform drug content.

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