European Journal of Biomedical and Pharmaceutical Sciences

TO DETERMINE THE EFFECT OF DIFFERENT PENETRATION ENHANCERS ON RELEASE OF CAFFEINE FROM GEL FORMULATION

Mohit Kumar*, Dr. Shailesh Kumar Ghatuary, Mamta Dubey and Sarika Chaturvedi

ABSTRACT

The aim of present study is to determine the effect of different penetration enhancers on release of caffeine from gel formation this research was carried out by pre-formulation studies such as, physical appearance, UV and melting point determination. The optimized formulation was characterized by parameters like drug content, spread ability of gel, pH, ex-vivo and drug diffusion study. Ex -vivo study on the pig ear skin model and accelerated stability studies were done. Melting point of caffeine was found to be within the range i.e., 235-238°C. The UV maxima were found to be 273nm. The pH of caffeine gel formulations was found in the range of 5.34 to 6.19. Caffeine gel was prepared using different penetration enhancers like Ethanol, Glycerin, PEG-400 and PEG-200. The best gel was selected on the bases of drug permeation results. The formulation having Ethanol as penetration enhancer was found to be best formulation as it gives maximum skin, permeation results.

Keywords: Penetration enhancer, caffeine gel, UV spectroscopy, skin permeation, Transdermal drug delivery.