European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANTI-AGGRESSIVE ACTIVITY OF MATRICARIA CHAMOMILLA OIL IN RODENTS

Shilpi Chaturvedi*, Sarika Chaturvedi**, Mamta Dubey**, Akansha Bhadouria** and Deeksha Shakya***

ABSTRACT

Aggression is apparent, frequently hurtful, communal communication through the meaning of exact damage or new rudeness upon a new individual. It is an almost universal activity with animals. It can occur either in revenge or without irritation. In humans, disturbance due to blocked goals can reason aggression. Obedience may be viewed because the reverse of aggressiveness. In definitions usually working in the social sciences and behavioral sciences, aggression is an answer by an person that delivers a little disagreeable to another being. About 20 Mice (20-30g) female sex was randomly divided four groups as well as each group contains five rats .The five group are Control group, Standard group (Diazepam 1mg/kg i.p. Treated group), Test dose 1 group (Matricaria chamomilla oil 250mg/kg p.o. treated group), Test dose 2 group (Matricaria chamomilla oil 500mg/kg p.o. treated group).The outcome of the result of Matricaria chamomilla oil on open field test. water competition test, forced swim test and isolatition induced aggression was evaluated in mice. The effect of control treated, diazepam treated (1mg/kg i.p.), And Matricaria chamomilla oil 250mg/kg p.o. and Matricaria chamomilla oil 500mg/kg p.o. body weight was evaluated at usual treatment. The depression function was assessed in the water competition test the average time of spout possession and frequency of spout possession in the water competition test are depict at a dose of 250mg/kg and 500mg/kg produced a significant decrease in spout gaining frequency along with a reduction in time spent. In open field test The M.Chamomilla oil at the dose of 250mg/kg and 500mg/kg produced a significant prolonged number of square Visited in center, number of square visited in periphery and time spent in center which was found to be statistically significant compared to control and rearing time is no significant data. My information recommended the Matricaria Chamomilla of 500mg/kg shows better result in comparison to Matricaria Chamomilla 250mg/kg and Aggressive problems can be diverse.

Keywords: Matricaria chamomilla oil, diazepam, open field, Isolation-induced aggression.