Abstract
EVALUATION OF THE ABILITY OF A RECIPE EXTRACT COMPOSED OF THE LEAVES OF THREE FOOD PLANTS TO REVERSE PHENYL HYDRAZINE-INDUCED ANEMIA IN WISTAR RATS: CEIBA PENTANDRA, IPOMEA BATATAS AND SPINACIA OLERACEAE

Assi Anicet AGNISSAN, Joel AKAKPO-AKUE, Patrick Aubin DAKIA*, Yvan- Andréa Yahaut KONAN, Alico Joseph Djaman, Kouakou BROU

ABSTRACT

Anemia is a public health problem that mainly affects people in various countries. It would be interesting to identify food plants that, while meeting food needs, restore at the same time, the anemic state of populations. This present study was therefore conducted to evaluate the ability of a recipe extract composed of the leaves of three food plants (Ceiba pentandra, Ipomoea batatas and Spinacia oleracea) to reverse phenyl hydrazine-induced anemia in Wistar rats. So, the phenolic compounds, mineral profile, acute toxicity and antianemia activity of recipe extract were evaluated. The results showed that the yield of extraction was 20.7 ± 2.1 % and revealed the presence of polyphenols (821.6 mg/100 g), flavonoids (99.8 mg/100 g), tannins (108 mg/100 g) and iron (190.14 mg/100 g). The acute toxicity test did not cause any mortality, nor any sign of toxicity at the dose of 2000 mg/Kg bw. Antianemia activity showed that the oral administration of the recipe extract at the doses of 200, 400 and 800 mg/Kg bw and standard treatment with folic acid resulted in anemic rats returning to normal levels of red blood cells, hemoglobin and hematocrit compared to non-anemic control rats. The red blood cell count increased from 3.4 ±1.70 to 7.65±3.58.106/μL; hemoglobin increased from 6.7±3.61 g/dL to 13.6±7.13g/dL and haematocrits from 23.2±2.53 % to 45.5±3.09 %. This study highlighted the antianemic activity of the recipe extract. This antianemic property could be due to the presence of polyphenols, flavonoids, tannins and iron in the recipe extract.

Keywords: Antianemic activity, mineral profile, Phenolic compounds, food plants, Ceiba pentandra, Ipomoea batatas, Spinacia oleracea.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MARCH ISSUE PUBLISHED

    MARCH 2024 Issue has been successfully launched on 1 MARCH 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT