Abstract
THERAPEUTIC EFFECT OF MULBERRY LEAF EXTRACT ON CARDIAC OXIDATIVE STRESS IN TYPE 2 DIABETIC MALE RATS

Hoda. A. Mansour, Reham M. Morsi, Doaa S. Mansour* and Manal Mohammad Morsy

ABSTRACT

Diabetic complications result from long-term hyperglycemia that causes macrovascular and microvascular damage, endangering the heart. Therefore this study was conducted to evaluate the cardioprotective effect, antioxidant activity and anti-diabetic effect of mulberry (Morus alba L.) leaf extracts in diabetic rats. Streptozotocin was injected in male Wistar rats to induce type 2 diabetes. After confirmation of diabetes, animals were treated orally with mulberry dried leaf extracts (600 mg/kg) everyday for 4 weeks. Mulberry leaf extract was effective in lowering blood glucose, Glycosylated hemoglobin, Nitric oxide, malondialdehyde (MDA) and increasing insulin level and markers of cardiac oxidative stress including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX). Lipid profiles including total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-c), and very low-density lipoprotein cholesterol (VLDL) were significantly decreased whereas high-density lipoprotein cholesterol (HDL-c) and adipsin were significantly increased in the treated diabetic rats which were treated with Mulberry leaf extract in comparison to the diabetic control (p<0.05).The results confirm the effect of mulberry on modulation of glucose metabolism through correcting hyperglycaemia, increasing insulin secretion, and improving cardiac oxidative stress parameters in STZ- induced diabetic rat model and also emphasize the effectiveness of Adipsin as a novel prognostic biomarker for cardiovascular diseases.

Keywords: Diabetes, Cardiac Oxidative stress, Mulberry leaf extract, Adipsin.


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