Abstract
CUBOSOMES IN THE TREATMENT OF HERPES SIMPLEX VIRAL INFECTION

Sandeep Kumar Jain*, Krishnananda Kamath K., Vindhya V.S. and Shabaraya A.R.

ABSTRACT

Cubosomes are lipid cubic phase nanoparticles that are extremely stable and supported by a polymer-based outer corona. A single lipid bilayer is the basis of lipid cubic phases, which consist of a continuous periodic membrane lattice structure with pores made of two interlaced water channels. Cubosomes often have "honey combed" structures and are thermodynamically stable. The polymer outer corona of cubosomes can be employed for targeting, and they are extremely stable under physiological settings. Cubosome composition can be adjusted to alter pore diameters or add bioactive lipids. Because the cubosome form offers a substantially greater membrane surface area than liposomes, tiny membrane proteins and small medicinal molecules can be put into them. The cubosome can enclose hydrophobic, hydrophilic, and amphiphilic molecules. Herpes simplex virus (HSV) is a viral infection causes a variety of infections including cutaneous and oro-facial herpes, varicella zoster infections, genital herpes, chicken pox, and herpes keratitis. Antiviral medication prescriptions are the current HSV infection treatment. Many medications, including acyclovir, valacyclovir, and famciclovir, are prescribed.

Keywords: Cubosomes, Nano particles, bioactive lipids, Herpes simplex virus.


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